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Protoxin II / ProTx-II
簡(jiǎn)要描述：Smartox Biotechnology是*一家專門生產(chǎn)動(dòng)物毒液多肽毒素，用于細(xì)胞離子通道功能研究的生物醫(yī)藥公司。多肽毒素在生物制藥領(lǐng)域具有重要的使用價(jià)值。
產(chǎn)品型號(hào)：07PTX002- 廠商性質(zhì)：代理商
- 更新時(shí)間：2025-07-02
- 訪 問(wèn) 量：1767
產(chǎn)品介紹
Protoxin II / ProTx-II
Nav1.7 selective inhibitor(鈉離子通道Nav1.7選擇性抑制劑)
ProTx-II (ProTx-2, Protoxin II) is a toxin that was originally isolated from Thrixopelma pruriens (Peruvian green velvet tarantula). ProTx-II inhibits both tetrodotoxin-sensitive and tetrodotoxin-resistant voltage-gated sodium channels.ProTx-II inhibits activation by shifting the voltage-dependence of channel activation to more positive potentials. ProTx-II blocks Nav1.7 with an IC50 value of around 300 pM, Nav1.2, Nav1.5 and Nav1.6 with IC50 values of 41 nM, 79 nM and 26 nM respectively. It also acts on Cav3.1/CACNA1G and interacts more weakly with the related T-Type channel Cav3.2/CACNA1H but potently inhibits the L-type calcium channel Cav1.2/CACNA1C. ProTx-II blocks action potential propagation in nociceptors.
ProTx-II 技術(shù)資料
氨基酸序列：
Tyr-Cys2-Gln-Lys-Trp-Met-Trp-Thr-Cys9-Asp-Ser-Glu-Arg-Lys-Cys15-Cys16-Glu-Gly-Met-Val-Cys21-Arg-Leu-Trp-Cys25-Lys-Lys-Lys-Leu-Trp-OH
二硫鍵：Cys2-Cys16, Cys9-Cys21 and Cys15-Cys25
長(zhǎng)度 (aa)： 30
分子式： C168H250N46O41S8
分子量：3828.00 Da
外觀： White lyophilized solid
可溶性：water and saline buffer
CAS 號(hào)：484598-36-9
來(lái)源： Synthetic
純度：> 95 %
產(chǎn)品信息
07PTX002-00100 | ProTx-II | 0.1mg |
07PTX002-00500 | ProTx-II | 0.5mg |
07PTX002-01000 | ProTx-II | 1mg |
